Back
Molecular characteristics of metastatic liver lesions in uveal melanoma: the search for therapeutic targets
Mr Andrew Dodson
Dr Helen Kalirai
Dr Sarah Lake
Prof. Sarah Coupland
Prof. Bertil Damato
Summary
In a proportion of patients with an eye cancer known as uveal melanoma, cancer cells will spread from the eye to a second site, usually the liver. Such spread (known as metastatic disease) may occur despite successful treatment of the eye cancer. At present, neither liver surgery nor medications have helped to increase the life expectancy of patients with metastatic disease. This is because little is known about the characteristics of the cancer cells from the eye that are able to grow in the liver. We are conducting a study that aims to understand more about these cells and will identify factors that can be drug targets, to prevent or slow down cancer cell growth.
Dr Helen Kalirai
Dr Sarah Lake
Prof. Sarah Coupland
Prof. Bertil Damato
Summary
In a proportion of patients with an eye cancer known as uveal melanoma, cancer cells will spread from the eye to a second site, usually the liver. Such spread (known as metastatic disease) may occur despite successful treatment of the eye cancer. At present, neither liver surgery nor medications have helped to increase the life expectancy of patients with metastatic disease. This is because little is known about the characteristics of the cancer cells from the eye that are able to grow in the liver. We are conducting a study that aims to understand more about these cells and will identify factors that can be drug targets, to prevent or slow down cancer cell growth.
Funded by:
