Liverpool Ocular Oncology<br />Research Group
 
  • HOME
  • NEWS
  • Research Team
  • Disease Focus and Research
    • Uveal Melanoma
    • Conjunctival melanoma
    • Ocular Adnexal Lymphoma
  • Molecular Pathology
  • Ocular Oncology Biobank (OOB)
  • Paper Publications
    • 2022
    • 2021
    • 2020
    • 2019
    • 2018
    • 2017
    • 2016
    • 2015
    • 2014
    • 2013
    • 2012
    • 2011
    • 2010
    • 2009
    • 2008
    • 2007
    • 2006
    • 2005
    • 2004
  • Book Chapters
  • Informative Videos
  • Alumni
    • Previous Staff
    • Past PhD Students
    • Past MD Students
    • Past MRes Students
    • Past BSc/MSc Students
    • Nuffield Students
  • Visitors
    • Visiting researchers and clinicians
    • Visiting Students
  • Support Us/Donations
  • Fundraising Events
  • Training and Opportunities
  • Contact us
  • Links

2020

Validation Of The Newly Proposed Who Classification System For Conjunctival Melanocytic Intraepithelial Lesions: A Comparison With The 'C-MIN' And 'PAM' Classification Schemes.

Milman T, Eiger-Moscovich M, Henry RK, Folberg R, Coupland SE, Grossniklaus HE, Mudhar HS, Eberhart CG, Heegaard S, Auw-Hädrich C, Herwig-Carl MC, Löffler KU, Cherepanoff S, Zhang Q, Sharpe JE, See TRO, Shields CL, Eagle RC Jr.
Am J Ophthalmol. 2020 Oct 29:S0002-9394(20)30588-2. doi: 10.1016/j.ajo.2020.10.020.
online ahead of print.PMID: 33130046

​Leukotriene B4 (LTB4) and its receptor in Experimental Autoimmune Uveitis (EAU) and in human retinal tissues: clinical severity and LTB4-dependence of retinal Th17 cells.

Eskandarpour M, Chen YH, Nunn MA, Coupland SE, Weston-Davies W, Calder VL.
Am J Pathol. 2020 Nov 4:S0002-9440(20)30491-0. doi: 10.1016/j.ajpath.2020.10.010.
​Online ahead of print.
PMID: 33159884
​

Optic nerve head sarcoidosis mimicking an intraocular tumour, and occurring as the first manifestation of neuro-ocular sarcoidosis 

Yamini Krishna Louise Christou  Jakub Khzouz  Rumana Hussain  Heinrich Heimann Sarah E. Coupland 
https://doi.org/10.1016/j.ajoc.2020.100988

The reproduction of human pathology specimens using three-dimensional (3D) printing technology for teaching purposes. 

McMenamin PG, Hussey D, Chin D, Alam W, Quayle MR, Coupland SE, Adams JW.
Med Teach. 2020 Oct 26:1-9.
doi: 10.1080/0142159X.2020.1837357. Online ahead of print.
PMID: 33103933 ​
Validation Of The Newly Proposed Who Classification System For Conjunctival Melanocytic Intraepithelial Lesions: A Comparison With The 'C-MIN' And 'PAM' Classification Schemes.
Milman T, Eiger-Moscovich M, Henry RK, Folberg R, Coupland SE, Grossniklaus HE, Mudhar HS, Eberhart CG, Heegaard S, Auw-Hädrich C, Herwig-Carl MC, Löffler KU, Cherepanoff S, Zhang Q, Sharpe JE, See TRO, Shields CL, Eagle RC Jr.

Am J Ophthalmol. 2020 Oct 29:S0002-9394(20)30588-2. doi: 10.1016/j.ajo.2020.10.020.
online ahead of print.PMID: 33130046

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells

by Kayleigh Slater 1,2, Aisling B. Heeran 3, Sandra Garcia-Mulero 4,5, Helen Kalirai 6, Rebeca Sanz-Pamplona 4, Arman Rahman 1, Nebras Al-Attar 1, Mays Helmi 7, Fiona O’Connell 3, Rosa Bosch 8, Anna Portela 8, Alberto Villanueva 8, William M. Gallagher 1, Lasse D. Jensen 7, Josep M. Piulats 9,10, Sarah E. Coupland 6,11, Jacintha O’Sullivan 3 and Breandán N. Kennedy 1,*
  • PMID: 33066024
  • DOI: 10.3390/cancers12102950

Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma.

Krishna Y, Acha-Sagredo A, Sabat-Pośpiech D, Kipling N, Clarke K, Figueiredo CR, Kalirai H,Coupland SE.
Cancers (Basel). 2020 Sep 30;12(10):E2832. doi: 10.3390/cancers12102832.
PMID: 33008022
​

Conditional Survival in Uveal Melanoma.

Zabor EC, Radivoyevitch T, Singh AD, Kilic E, de Klein JEMM, Kalirai H, Coupland SE.
Ophthalmol Retina. 2020 Sep 23:S2468-6530(20)30395-X. doi: 10.1016/j.oret.2020.09.015.
Online ahead of print.PMID: 3297955  PDF VERSION

Conjunctival melanoma treatment outcomes in 288 patients: a multicentre international data-sharing study

Puneet Jain  1 , Paul T Finger  2 , Maria Fili  3 , Bertil Damato  4 , Sarah E Coupland  5 , Heinrich Heimann  5 , Nihal Kenawy  6 , Niels J Brouwer  7 , Marina Marinkovic  7 , Sjoerd G Van Duinen  7 , Jean Pierre Caujolle  8 , Celia Maschi  8 , Stefan Seregard  3 , David Pelayes  9 , Martin Folgar  9 , Yacoub A Yousef  10 , Hatem Krema  11 , Brenda Gallie  11 , Alberto Calle-Vasquez  12 , American Joint Committee on Cancer Ophthalmic Oncology Task Force
PMID: 32892167 DOI: 10.1136/bjophthalmol-2020-316293

Piloting a Deep Learning Model for Predicting Nuclear BAP1 Immunohistochemical Expression of Uveal Melanoma from Hematoxylin-and-Eosin Sections

Hongrun Zhang; Helen Kalirai; Amelia Acha-Sagredo; Xiaoyun Yang; Yalin Zheng; Sarah E. Coupland
Translational Vision Science & Technology September 2020, Vol.9, 50. doi:https://doi.org/10.1167/tvst.9.2.50

MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators

by Karen Aughton 1,*, Helen Kalirai 1,2 and Sarah E. Coupland 1,2
*Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(16), 5648; https://doi.org/10.3390/ijms21165648
Received: 16 July 2020 / Revised: 31 July 2020 / Accepted: 4 August 2020 / Published: 6 August 2020
(This article belongs to the Special Issue Genetic Basis and Molecular Mechanisms of Uveal Melanomas)
View Full-Text Download PDF

Melanoblasts Populate the Mouse Choroid Earlier in Development Than Previously Described
Paul G. McMenamin; Graham T. Shields; Yashar Seyed-Razavi; Helen Kalirai; Robert H. Insall; Laura M. Machesky; Sarah E. Coupland
Investigative Ophthalmology & Visual Science August 2020, Vol.61, 33. doi:https://doi.org/10.1167/iovs.61.10.33
​
Characterization of Uveal Melanoma Cell Lines and Primary Tumor Samples in 3D Culture
Aughton K, Shahidipour H, Djirackor L, Coupland SE, Kalirai H.

Trans Vis Sci Tech. 2020;9(7):39
https://doi.org/10.1167/tvst.9.7.39

Iris lymphoma - a systematic guide for diagnosis and treatment.
Kakkassery V, Coupland SE, Heindl LM.
Surv Ophthalmol. 2020 Jun 22:S0039-6257(20)30100-4. doi: 10.1016/j.survophthal.2020.06.003. Online ahead of print.

Lymphoma of the lacrimal gland - An International Multicenter Retrospective Study. Vest SD, Mikkelsen LH, Holm F, Rasmussen PK, Hindso TG, Knudsen MKH, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Mulay K, Sjö LD, Sniegowski ME, Vemuganti GK, Thuro BA, Heegaard S.Am J Ophthalmol. 2020 Jun 20:S0002-9394(20)30311-1. doi: 10.1016/j.ajo.2020.06.015. Online ahead of print.PMID: 32574779

Image Analysis 3D Conjunctival Melanoma Cell Cultures Following Electrochemotherapy
Miltiadis Fiorentzis, Periklis Katopodis, Helen Kalirai, Berthold Seitz, Arne Viestenz and Sarah E. Coupland
Received: 25 April 2020; Accepted: 9 June 2020; Published: 13 June 2020

Ano-uro-genital mucosal melanoma UK national guidelines

Henry G Smith, Izhar Bagwan, Ruth E Board, Sharon Capper, Sarah E Coupland, Jessica Glen, Susan Lalondrelle, Antonia Mayberry, Asif Muneer, Karen Nugent, Pubudu Pathiraja, Miranda Payne, Howard Peach, Jonathan Smith, Sarah Westwell, Ewan Wilson, Simon Rodwell, Martin Gore, Nancy Turnbull, Myles J F Smith​

Spontaneous Necrosis of a Large Choroidal Melanoma: Unusual Presentation in a 49-Year-Old Male

Baumann C, Iannetta D, Coupland SE, Groenewald C, Vishwanath M, Heimann H.Ocul Oncol Pathol. 2020 May;6(3):174-179. doi: 10.1159/000501522. Epub 2019 Dec 5.PMID: 32509762
​

Potential Onco-Suppressive Role of miR122 and miR144 in Uveal Melanoma through ADAM10 and C-Met Inhibition

Adriana Amaro, Michela Croce, Silvano Ferrini, Gaia Barisione, Marina Gualco, Patrizia Perri, Ulrich Pfeffer, 
Martine J Jager, Sarah E Coupland, Carlo Mosci, Gilberto Filaci, Marina Fabbi, Paola Queirolo, Rosaria Gangemi.

Cancers 2020, 12(6), 1468; https://doi.org/10.3390/cancers12061468 (registering DOI)
Received: 18 May 2020 / Revised: 1 June 2020 / Accepted: 2 June 2020 / Published: 4 June 2020
​

Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons

Rumana N. Hussain, Sarah E. Coupland, Jakub Khzouz, Helen Kalirai, Jason L. Parsons
Open Access Article

Cancers 2020
(This article belongs to the Special Issue Proton Therapy For Cancers)

Primary Vitreoretinal Lymphoma in HIV Infection

Jonel Steffen, Sarah E. Coupland & Justine R. Smith
To cite this article: Jonel Steffen, Sarah E. Coupland & Justine R. Smith
(2020):
Primary Vitreoretinal Lymphoma in HIV Infection, Ocular Immunology and Inflammation,
DOI:10.1080/09273948.2020.1751856
Published online: 26 May 2020.

Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma

Sophie Thornton, Sarah E. Coupland,  Lisa Olohan, Julie S. Sibbring, John G. Kenny, Christiane Hertz-Fowler, Xuan Liu, Sam Haldenby, Heinrich Heimann, Rumana Hussain, Natalie Kipling, Azzam Taktak, Helen Kalirai.
View Full-Text Download PDF
Browse Figures

Parsimonious Models for Predicting Mortality from Choroidal Melanoma.

Damato B, Eleuteri A, Hussain R, Kalirai H, Thornton S, Taktak A, Heimann H, Coupland SE.
Invest Ophthalmol Vis
Sci. 2020 Apr 9;61(4):35. doi: 10.1167/iovs.61.4.35.PMID: 32334433
​
Electrochemotherapy in 3D ocular melanoma spheroids using a customized electrode.
Fiorentzis, M., Viestenz, A., Seitz, B., Coupland, S. E., Heinzelmann, J.
J. Vis. Exp. (158), e60611, doi:10.3791/60611 (2020).
www.jove.com/pdf/60611/jove-protocol-60611-electrochemotherapy-3d-ocular-melanoma-spheroids-using-customized


​A possible role for hepcidin in the detection of iron deficiency in severely anaemic HIV-infected patients in Malawi.
Huibers MHW, Calis JC, Allain TJ, Coupland SE, Phiri C, Phiri KS, Swinkels DW, Boele van Hensbroek M, Bates I.
PLoS One. 2020 Feb 27;15(2):e0218694. doi: 10.1371/journal.pone.0218694. eCollection 2020.
Free PMC ArticleSimilar articles

Severe anaemia complicating HIV in Malawi; Multiple co-existing aetiologies are associated with high mortality.
Huibers MHW, Bates I, McKew S, Allain TJ, Coupland SE, Phiri C, Phiri KS, Boele van Hensbroek M, Calis JC.
PLoS One. 2020 Feb 25;15(2):e0218695. doi: 10.1371/journal.pone.0218695. eCollection 2020
Free PMC ArticleSimilar articles

Multicenter External Validation of the Liverpool Uveal Melanoma Prognosticator Online: An OOG Collaborative Study.
Cunha Rola A, Taktak A, Eleuteri A, Kalirai H, Heimann H, Hussain R, Bonnett LJ, Hill CJ, Traynor M, Jager MJ, Marinkovic M, Luyten GPM, Dogrusöz M, Kilic E, de Klein A, Smit K, van Poppelen NM, Damato BE, Afshar A, Guthoff RF, Scheef BO, Kakkassery V, Saakyan S, Tsygankov A, Mosci C, Ligorio P, Viaggi S, Le Guin CHD, Bornfeld N, Bechrakis NE, Coupland SE.
Cancers (Basel). 2020 Feb 18;12(2). pii: E477. doi: 10.3390/cancers12020477
Free ArticleSimilar articles

Lenalidomide, dexamethasone and alemtuzumab or ofatumumab in high-risk chronic lymphocytic leukaemia: final results of the NCRI CLL210 trial.
Pettitt AR, Jackson R, Cicconi S, Polydoros F, Yap C, Dodd J, Bickerstaff M, Stackpoole M, Khan UT, Carruthers S, Oates M, Lin K, Coupland SE, Menon G, Kalakonda N, McCarthy H, Bloor A, Schuh A, Duncombe A, Dearden C, Fegan C, Kennedy B, Walewska R, Marshall S, Fox CP, Hillmen P.
Haematologica. 2020 Feb 13. pii: haematol.2019.230805. doi: 10.3324/haematol.2019.230805. [Epub ahead of print] 
Free ArticleSimilar articles
​
Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis.
Thornton S, Coupland SE, Heimann H, Hussain R, Groenewald C, Kacperek A, Damato B, Taktak A, Eleuteri A, Kalirai H.  Br J Ophthalmol. 2020 Feb 5. pii: bjophthalmol-2019-315363. doi: 10.1136/bjophthalmol-2019-315363.

Software-assisted decision support in digital histopathology.
Huss R, Coupland SE.
J Pathol. 2020 Jan 28. doi: 10.1002/path.5388. [Epub ahead of print] Review.

Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.
Figueiredo CR, Kalirai H, Sacco JJ, Azevedo RA, Duckworth A, Slupsky JR, Coulson JM, Coupland SE.
​
Journal of Pathology. 2020 Apr;250(4):420-439.doi: 10.1002/path.5384.
Importance of Partial Losses of Chromosome 3 in Uveal Melanoma in the BAP1 Gene Region
Sarah E. Coupland, Sophie Thornton, Helen Kalirai
Publication Date: 01-02-2020

Powered by Create your own unique website with customizable templates.