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Name:
Qualifications: Position: E-mail: |
Address:
Molecular and Clinical Cancer Medicine
Institute of Translational Medicine
University of Liverpool
6th Floor, Duncan Building
Daulby Street
Liverpool
L69 3GA
Research Interests:
My research interests lie in the genetic deregulation occurring during carcinogenesis and its functional significance, in particular the changes that allow tumour initiation and drive metastasis. Using high resolution molecular genetic methods my research aims to better understand uveal and conjunctival melanoma (ocular cancer) pathogenesis and, through this, identify novel therapeutic targets for the treatment of primary and metastatic tumours.
Key Projects
Functional validation of “druggable” targets in uveal melanoma
Identification of regulators of metastasis
Molecular characteristics of metastatic liver lesions in uveal melanoma: the search for therapeutic targets
Comparative digital transcriptional profiling of canine and human uveal melanomas
Conjunctival melanoma: a multicentre study correlating baseline features with histology and genetics
Gross chromosomal abnormalities in iris melanoma
Publications
Mutations in G Protein Encoding Genes and Chromosomal Alterations in Primary Leptomeningeal Melanocytic Neoplasms.
Küsters-Vandevelde HV, van Engen-van Grunsven IA, Coupland SE, Lake SL, Rijntjes J, Pfundt R, Küsters B, Wesseling P, Blokx WA, Groenen PJ.
Pathol Oncol Res. 2014 Oct 15.
Authors’ reply.
Lake SL, Kalirai H, Dodson AR, Coupland SE, Lloyd BH, Damato BE, Taktak AF.
Am J Pathol. 2013 Aug;183(2):638-40.
Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival.
Lake SL, Damato BE, Kalirai H, Dodson AR, Taktak AF, Lloyd BH, Coupland SE.
Am J Pathol. 2013 Mar;182(3):678-87. doi: 10.1016/j.ajpath.2012.11.036. Epub 2013 Jan 26.
Conjunctival melanoma and melanocytic intra-epithelial neoplasia.
Kenawy N, Lake SL, Coupland SE, Damato BE.
Eye (Lond). 2013 Feb;27(2):142-52. doi: 10.1038/eye.2012.254. Epub 2012 Dec 7. Review.
Molecular pathology of uveal melanoma.
Coupland SE, Lake SL, Zeschnigk M, Damato BE.
Eye (Lond). 2013 Feb;27(2):230-42. doi: 10.1038/eye.2012.255. Epub 2012 Dec 7. Review.
Comparison of formalin-fixed and snap-frozen samples analyzed by multiplex ligation-dependent probe amplification for prognostic testing in uveal melanoma.
Lake SL, Kalirai H, Dopierala J, Damato BE, Coupland SE.
Invest Ophthalmol Vis Sci. 2012 May 4;53(6):2647-52. doi: 10.1167/iovs.12-9584. Print 2012 May.
Combined p53 and MDM2 biomarker analysis shows a unique pattern of expression associated with poor prognosis in patients with renal cell carcinoma undergoing radical nephrectomy BJU Int.
Noon AP, Polan´ski R, El-Fert AY, Kalirai H, Shawki H, Campbell F, Dodson AR, Eccles RM, Lloyd BH, Sibson DR, Coupland SE, Lake SL, Parsons K, Vlatkovic´ N, Boyd MT.
2012 Apr;109(8):1250-7.
GDF-15: a novel serum marker for metastases in uveal melanoma patients.
Suesskind D, Schatz A, Schnichels S, Coupland SE, Lake SL, Wissinger B, Bartz-SchmidtKU and Henke-FahleS.
Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):887-95
Multiplex ligation-dependant probe amplification of conjunctival melanoma reveals frequent BRAF V600E gene mutation and gene copy number changes.
Lake SL, Jmor F, Dopierala J, Taktak AFG, Coupland SE. Damato BE.
Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5598-604.
Multiplex ligation-dependent probe amplification analysis of uveal melanoma with extraocular extension demonstrates heterogeneity of gross chromosomal abnormalities
Lake SL, Damato BE,Dopierala J, Taktak AFG, Coupland SE.
Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5559-64.
Whole-genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma
Lake SL, Coupland SE, Taktak AFG, Damato BE.
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4884-91.
Genetic heterogeneity in uveal melanoma assessed by multiplex ligation-dependent probe amplification.
Dopierala J, Lake SL, Coupland SE, Taktak AFG, Damato B.
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4898-905.
Proteomics of uveal melanomas suggests HSP-27 as a possible surrogate marker of chromosome 3 loss.
Coupland SE, Vorum H, Mandal N, Kalirai H, Honoré B, Urbak SF, Lake SL, Dopierala J, Damato BE.
Invest Ophthalmol Vis Sci. 2010 Jan;51(1):12-20.
Molecular and Clinical Cancer Medicine
Institute of Translational Medicine
University of Liverpool
6th Floor, Duncan Building
Daulby Street
Liverpool
L69 3GA
Research Interests:
My research interests lie in the genetic deregulation occurring during carcinogenesis and its functional significance, in particular the changes that allow tumour initiation and drive metastasis. Using high resolution molecular genetic methods my research aims to better understand uveal and conjunctival melanoma (ocular cancer) pathogenesis and, through this, identify novel therapeutic targets for the treatment of primary and metastatic tumours.
Key Projects
Functional validation of “druggable” targets in uveal melanoma
Identification of regulators of metastasis
Molecular characteristics of metastatic liver lesions in uveal melanoma: the search for therapeutic targets
Comparative digital transcriptional profiling of canine and human uveal melanomas
Conjunctival melanoma: a multicentre study correlating baseline features with histology and genetics
Gross chromosomal abnormalities in iris melanoma
Publications
Mutations in G Protein Encoding Genes and Chromosomal Alterations in Primary Leptomeningeal Melanocytic Neoplasms.
Küsters-Vandevelde HV, van Engen-van Grunsven IA, Coupland SE, Lake SL, Rijntjes J, Pfundt R, Küsters B, Wesseling P, Blokx WA, Groenen PJ.
Pathol Oncol Res. 2014 Oct 15.
Authors’ reply.
Lake SL, Kalirai H, Dodson AR, Coupland SE, Lloyd BH, Damato BE, Taktak AF.
Am J Pathol. 2013 Aug;183(2):638-40.
Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival.
Lake SL, Damato BE, Kalirai H, Dodson AR, Taktak AF, Lloyd BH, Coupland SE.
Am J Pathol. 2013 Mar;182(3):678-87. doi: 10.1016/j.ajpath.2012.11.036. Epub 2013 Jan 26.
Conjunctival melanoma and melanocytic intra-epithelial neoplasia.
Kenawy N, Lake SL, Coupland SE, Damato BE.
Eye (Lond). 2013 Feb;27(2):142-52. doi: 10.1038/eye.2012.254. Epub 2012 Dec 7. Review.
Molecular pathology of uveal melanoma.
Coupland SE, Lake SL, Zeschnigk M, Damato BE.
Eye (Lond). 2013 Feb;27(2):230-42. doi: 10.1038/eye.2012.255. Epub 2012 Dec 7. Review.
Comparison of formalin-fixed and snap-frozen samples analyzed by multiplex ligation-dependent probe amplification for prognostic testing in uveal melanoma.
Lake SL, Kalirai H, Dopierala J, Damato BE, Coupland SE.
Invest Ophthalmol Vis Sci. 2012 May 4;53(6):2647-52. doi: 10.1167/iovs.12-9584. Print 2012 May.
Combined p53 and MDM2 biomarker analysis shows a unique pattern of expression associated with poor prognosis in patients with renal cell carcinoma undergoing radical nephrectomy BJU Int.
Noon AP, Polan´ski R, El-Fert AY, Kalirai H, Shawki H, Campbell F, Dodson AR, Eccles RM, Lloyd BH, Sibson DR, Coupland SE, Lake SL, Parsons K, Vlatkovic´ N, Boyd MT.
2012 Apr;109(8):1250-7.
GDF-15: a novel serum marker for metastases in uveal melanoma patients.
Suesskind D, Schatz A, Schnichels S, Coupland SE, Lake SL, Wissinger B, Bartz-SchmidtKU and Henke-FahleS.
Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):887-95
Multiplex ligation-dependant probe amplification of conjunctival melanoma reveals frequent BRAF V600E gene mutation and gene copy number changes.
Lake SL, Jmor F, Dopierala J, Taktak AFG, Coupland SE. Damato BE.
Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5598-604.
Multiplex ligation-dependent probe amplification analysis of uveal melanoma with extraocular extension demonstrates heterogeneity of gross chromosomal abnormalities
Lake SL, Damato BE,Dopierala J, Taktak AFG, Coupland SE.
Invest Ophthalmol Vis Sci. 2011 Jul 29;52(8):5559-64.
Whole-genome microarray detects deletions and loss of heterozygosity of chromosome 3 occurring exclusively in metastasizing uveal melanoma
Lake SL, Coupland SE, Taktak AFG, Damato BE.
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4884-91.
Genetic heterogeneity in uveal melanoma assessed by multiplex ligation-dependent probe amplification.
Dopierala J, Lake SL, Coupland SE, Taktak AFG, Damato B.
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4898-905.
Proteomics of uveal melanomas suggests HSP-27 as a possible surrogate marker of chromosome 3 loss.
Coupland SE, Vorum H, Mandal N, Kalirai H, Honoré B, Urbak SF, Lake SL, Dopierala J, Damato BE.
Invest Ophthalmol Vis Sci. 2010 Jan;51(1):12-20.
