Last week we received Professor Sarah E. Coupland from Liverpool, as the Visiting Professor of InFLAMES. It has been delightful to watch her amazing lectures, in addition to a profound meditation on how to strive for a successful academic career with all the challenges that come along on all fronts, and still maintaining a noble meaningful life full of personal achievements. From a modest early career stage until coming to prominence as the president of different funding institutions and scientific societies, Sarah shared the most important tips and tricks we need to bear in mind for academic success, with the most important aspect being persistence. 

Sarah had a very busy schedule where she also managed to provide with excellent scientific lectures regarding rare tumors that hide the knowledge gaps of cancer immune escape. From her lectures, we could better grasp how difficult is to factor the most refractory cancer type to current immunotherapies, uveal melanoma. Despite the difficulties for developing proper in vivo models that would accelerate preclinical research in uveal melanoma, Sarah’s group advanced in establishing important scientific grounds, mostly given to the foundation of what is considered today one of the largest and successful biobanks for these rare intraocular tumors. 

It has been a good month for Figueiredo’s group (MIORG) as one of the contributors of the InFLAMES flagship: a significant grant from the Jane and Aatos Erkko Foundation was just awarded. This funding opportunity will support our Academy of Finland project in the development of new adjuvant treatments to improve current immunotherapies for both cutaneous and ocular melanomas, where Sarah is an active collaborator.

Carlos De Figueiredo - InFlames

​7.10.2021 at the Royal College of Pathologists in Alie Street, London.

Azzam is one of three members of The Institute of Physics and Engineering in Medicine honoured for their long and exceptional service to the Institute.

​IPEM Fellow Professor Azzam Taktak is Consultant Clinical Scientist/Honorary Professor at Liverpool University Hospitals NHS Trust.

Professor Taktak said: ‘I am extremely flattered and honoured to be awarded the Gold Medal for Exceptional Service. Over the last 20 years, I have joined many IPEM committees and served a number of offices, most notably being CEng Registrar between 2008 – 2012 and Vice President for Engineering between 2012 – 2015. I have also been a member of working groups such as Report 90 and Report 97 related to Electrical Safety of Medical Equipment. 

‘Being a member of the Institute has opened so many doors of opportunity for me, put me in touch with some of the leading names in the field and helped shape my career path in ways I could not have foreseen.’

Professor Stephen O’Connor, IPEM’s President, said of the award winners: ‘I initiated this Gold Medal in 2020 as there were no awards to recognise long and exceptional service to IPEM

The European Vision Institute is thrilled to announce the “TOP LIST of excellent Women in European Vision Research and Ophthalmology 2021”.  See full article
​Sarah Coupland
Q1: Although their presence has grown steadily for the past 3 decades, women hoping for a career in Vision Research and Ophthalmology still face many obstacles. What would be in your opinion the three most important steps to make the field more diverse?

a) Encourage Vision Research and Ophthalmology at the very earliest levels of education – i.e. in secondary schools in all socio-economic areas and countries, as well as undergraduates in medicine and biology.

b) Inform the public and their families about the wonders (and the importance) of the eye at outreach activities, e.g. museums, interacting with people of all ages, particularly the young school pupils and undergraduates in medicine and biology.

c) At the above events, provide flyers or interactive media, which show photos of women in vision and ophthalmology and people of diverse backgrounds, as surgeons or as leading lab scientists (not only as nurses), to provide an image of possible attainment to the audience. 

Q2: What is your professional achievement you are most proud of?

Being awarded the Naumann Prize for Ophthalmic Pathology in 2018 in Barcelona at the WOC. This is given out only every 4 years, after selection by an international committee.

Q3: To what extent do you have to blend your personal and your professional life to achieve a balance? What should change?

My professional and personal lives do indeed blend: it is difficult sometimes to draw boundaries between the two, particularly during the covid pandemic when virtual meetings are scheduled at all hours of the day! And yet it is important to do so, to maintain the success of both. One way I try to achieve a balance is by undertaking a range of outdoor activities – e.g. cycling or walking – which takes me away from my desk and enables me to be ‘unplugged’ for at least an hour a day!

Q4: The next time you talk to a 12-year-old girl who shows a passion for science and medicine, what would you most want her to know?

I would want her to know that it is not only possible for her to have such a career, but she could also be the best and a leader in either of these fields.

Prof. Sarah Coupland, MBBS, PhD, FRCPath
George Holt Chair of Pathology
Consultant Histopathologist @ Liverpool Clinical Laboratories
Vice President for Communications, Royal College of Pathologists
Lead of the Liverpool Ocular Oncology Research Group (LOORG)

The Power List 2021
Welcome to our annual celebration of the great and inspirational minds that underpin the medical laboratory 

The Power List 2020
From motivating mentors to trailblazing innovators, social media gurus to laboratory medicine heroes, it is the inspirational individuals who make laboratory medicine such a fantastic field. You nominated and our expert judging panels deliberated – and now, we proudly showcase this diversity of talent in The Pathologist’s 2020 Power List. 

What inspired you to the ophthalmic field?
My father was a medical oncologist and my mother was a nurse, so I grew up with “medical speak” over the dinner table – it became second nature to me. After graduating from medicine in Sydney, Australia, I moved to Berlin, Germany, and began a PhD in ophthalmology. I examined the immune mechanisms involved in corneal rejection, which meant performing corneal transplants in rats followed by histological and immunohistological examination of their eyes. And that’s how I rediscovered my enthusiasm for the morphological understanding of disease mechanisms.

After completing my PhD, I did a three-month elective with William Lee in Glasgow,UK – a period during which I finally made the decision to specialize in histopathology.

I then spent seven years training in general pathology with Harald Stein at the Charité Benjamin Franklin in Berlin – at that time a referral centre for lymphomas, head and neck surgery and ophthalmic tumors – and emerged with a number of pathology subspecialties under my belt.

You make it sound straightforward, but there were a few “bumps in the road…”
I’ve not encountered what I would consider true adversity, but I have experienced a number of challenges along the way. Learning German in my mid-twenties to a sufficient standard to work as a pathologist, write complicated medical reports, and teach students was particularly demanding. To complicate things further, human anatomy in the German medical system is still described in Latin, so I had to learn that as well!

The most dramatic (and literal) bump in the road was my pregnancy with triplets near the end of my pathology training. Unfortunately, my contract was due to end during my maternity leave, and there was concern that I would have a job to return to, in order to complete my training! Luckily, I was able to organize a phased return to work and I completed my training, two years after the children’s birth (despite the complication of HELLP syndrome (severe pre-eclampsia), which put all four of us in intensive care for a few weeks). After my final exams, I went on to submit my
Associate Professor thesis, becoming the first female “Privat Dozent” from the Stein lab.

I went on to submit my Associate Professor thesis, becoming the
first female “Privat Dozent” from the Stein lab.

What is unique about ophthalmic pathology?
As an ophthalmic pathologist concentrating on ocular oncology, I interact closely with clinical teams. Ophthalmological diagnoses are very reliant on morphology and images. The beauty of the eye – and the surrounding structures – is the ability to see many pathologies in situ in the patient, which can allow for easier interpretation of the samples. That being said, many cases are difficult because the eye samples can
be tiny! For example, intraocular biopsies of the choroid or vitreous can be very demanding; one is expected to ‘squeeze out’ as much information as possible: morphology, immunophenotype, and genotype.

My favorite aspect of the work is making a difficult diagnosis in a timely manner to improve a patient’s outcome. The typical scenario would be a vitreous biopsy for suspected vitreoretinal lymphoma. These are notorious for the fragility of the tumor cells and the relatively high rate of non-diagnostic samples. By working closely with the vitreoretinal surgeons, we have been able to make recommendations with respect to how the sample is taken, transported, and processed in the lab to improve the diagnostic yield. And that is essential because vitreoretinal lymphomas are highgrade tumors where diagnostic delays must be avoided.

If you could change one aspect of your field, what would it be?
I was taught that the pillars in the understanding of medicine are the “three Ps”: pathology, physiology and pharmacology. If we are to make progress in the understanding of the pathogenesis, prevention and treatment of disease, we have to invest in these cornerstones of scientific medicine. Academic pathology is one of the most fragile subspecialties in medicine at present, and we have to increase awareness of its importance and create initiatives to make it attractive and prevent its complete disappearance.

What can be done to make the ophthalmic field more diverse?
Surgical specialties all suffer from a male/female imbalance. This may be due unconscious bias within the individual, society, and within institutions. The issue must be addressed head-on, with women of all backgrounds being encouraged to enter ophthalmology and associated specialties, to take this career into consideration even when they are at secondary school before progressing into medicine at university. Through programs such as Women in Vision UK and ARVO’s Women’s Leadership Development Program, women can be supported through their entire clinical and research careers. Mentorship programs or networks should also be available, acting as a buddying system, so that women can tap into these whenever problems arise. Finally, male colleagues should be made aware of what obstacles are still present for progression of female ophthalmologists, and should be enlisted to help overcome these.

​What is your proudest professional achievement?
Receiving the ICO’s Award for Ophthalmic Pathology in 2018 at the World Ophthalmological Congress in Barcelona. This award is given out only every four years to someone who has consistently supported training and research in Eye Pathology. It was instigated by the late Gottfried (Fritz) and his wife, Lieselotte Naumann, of Erlangen, Germany, and involves an international competitive selection process. Together with William Lee from Glasgow, Naumann was one of my mentors during my training as an eye pathologist. To be chosen amongst the previous awardees was a great honour for me.

How has your life changed during the COVID-19 pandemic?
The pandemic has actually brought me closer to my research team. I used to rush between buildings, cities, and countries – but a lot of time can be saved through virtual platforms. I see my students and post-docs significantly more regularly than before.

If you could go back in time to give yourself some advice, what would
you say?
Pick your battles. Don’t waste time on things that take you away from science. And don’t spend too much time writing long emails!

Outside of work, what makes you happy?
My three children make me very happy and proud, and beyond them, I very much enjoy cycling, walking, photography, music, and delicious seafood (cooked by my husband)!