Liverpool Ocular Oncology Molecular Pathology Service
(LOOMPS)

We can help you to estimate the survival prognosis of your patients with uveal melanoma by investigating their tumour for genetic abnormalities.

We do this by performing multiplex ligation-dependent probe amplification (MLPA) and/or microsatellite analysis (MSA), as appropriate.

MLPA tests 31 gene loci on chromosomes 1p, 3, 6 and 8. This is done using the P027.B1 uveal melanoma kit produced by MRC Holland (www.mlpa.com). This procedure requires at least 100ng DNA at a concentration of 40ng/µl. (link to FAQs)

MSA examines 8 microsatellites on chromosome 3. It is reserved for samples that are inadequate for MLPA but which yield at least 10ng DNA. (link to FAQs)

By integrating chromosome 3 status with histological grade of malignancy and clinical TNM stage, we are able to estimate the 10-year survival probability, also taking the patient’s age and sex into account. This is done using a program we have developed (www.ocularmelanomaonline.com).

Please download our application form and instruction sheet below, which provides information on sample types and volumes, storage conditions and shipping. 
 

Application Form

Instruction Sheet

Our turnaround time has a maximum of 20 working days. You will only be charged for the test once it has been completed.

Contacting us to discuss your requirements and to organise a shipping date is recommended.

Liverpool Ocular Oncology Molecular Pathology Service operates Monday to Friday 08.00h – 16.00h

LOOMPS Operational Manager – Helen Kalirai BSc., PhD
h.kalirai@liv.ac.uk
00441517064869

LOOMPS Technologist – Maria Marcela Baudo BSc., PhD
m.baudo@liv.ac.uk
00441517064023